官智

（研究员、博导）

个人简介（300-500字）

1964年生于云南楚雄，云南大学获学士学位，中山大学获硕士和博士学位，后分别在瑞典隆德(Lund)大学分子生物物理系、瑞典乌普萨拉(Uppsala)大学有机化学系和英国伦敦大学Birkbeck学院生物和化学科学系从事博士后研究，2005年回澳门新莆京游戏网站任教，重庆市第二届学术技术带头人后备人选。先后主持国家自然科学基金面上项目2项、重庆市自然科学基金重点项目1项，重庆市自然科学基金项目2项，教育部留学回国人员科研启动基金1项，人事部留学人员科技活动项目1项。迄今, 在Angew Chem Int Ed、Green Chem、Org Let、Chem Commun、Adv Synth Catal、ChemSusChem、J Org Chem等国际学术刊物上发表SCI收录论文100余篇；获授权发明专利24项；研究成果获重庆市2015年度自然科学二等奖（排名第一）。研究工作两次被美国《化学与工程新闻》（Chemical & Engineering News，C&EN）报道。

联系方式

手机：15923061183

E-mail：guanzhi@swu.edu.cn

研究方向

绿色不对称合成方法，包括酶催化、光催化和电催化不对称合成方法研究

代表性论文、专著和专利（不超过20项）

[1]     Chun-Lin Dong, Xuan Ding, Lan-Qian Huang, Yan-Hong He*, Zhi Guan*. Merging visible light photocatalysis and L-/D-proline catalysis: direct asymmetric oxidative dearomatization of 2-arylindoles to access C2-quaternary indolin-3-ones. Organic Letters, 2020, 22(3), 1076-1080.

[2]     Yu-Jue Chen, Guo-Yan Zhang, Yan-Hong He*, Zhi Guan*. Aryl C-H amination initiated by laccase-mediated oxidation of 4-phenylurazole. Catalysis Science & Technology, 2019, 9(16), 4216-4221.

[3]     Li Tang, Jack H. Matuska, Yu-Han Huang, Yan-Hong He,* Zhi Guan*. Amide synthesis from thiocarboxylic acids and amines by spontaneous reaction and electrosynthesis. ChemSusChem, 2019, 12(12), 2570-2575.

[4]     Kai-Li Zuo, Yan-Hong He*, Zhi Guan*. Metal-free visible-light photocatalytic tandem radical addition-cyclization strategy for the synthesis of sulfonyl-containing isoquinolinediones. European Journal of Organic Chemistry, 2019, 2019 (5), 939-948.

[5]     Xuan Ding, Chun-Lin Dong, Zhi Guan*, Yan-Hong He*. Concurrent asymmetric reactions combining photocatalysis and enzymatic catalysis: direct enantioselective synthesis of 2,2-disubstituted indol-3-ones from 2-arylindoles. Angewandte Chemie International Edition, 2019, 58(1), 118-124.

[6]     Li Tang, Xing-Meng Li, Jack H. Matuska, Yan-Hong He,* and Zhi Guan*. Intramolecular transamidation of secondary amides via visible light induced tandem reaction. Organic Letters, 2018, 20 (18), 5618-5621.

[7]     Jing-Rui Xin, Yan-Hong He*, Zhi Guan*. Metal-free aerobic oxidative direct C-H amination of electron-deficient alkenes via photoredox catalysis. Organic Chemistry Frontiers, 2018, 5 (10), 1684-1688.

[8]     Jing-Wen Xue, Jun-Tao Guo, Yan-Hong He*, Zhi Guan*. Solvent controlled enzyme-catalyzed Friedel-Crafts reactions of indoles and isatins using α-chymotrypsin. Asian Journal of Organic Chemistry, 2017, 6(3), 297-304.

[9]     Meng-Jie Zhang, Griffin M Schroeder, Yan-Hong He*, Zhi Guan*. Visible light-mediated decarboxylative amination of indoline-2-carboxylic acids catalyzed by Rose Bengal. RSC Advances, 2016, 6(99), 96693-96699.

[10]   Yan-Hong He*, Yang Xiang, Da-Cheng Yang, Zhi Guan*. Combining enzyme and photoredox catalysis for aminoalkylation of indoles via a relay catalysis strategy in one pot. Green Chemistry, 2016, 18(19), 5325-5330.

[11]    Yan-Hong He*, Tao He, Jun-Tao Guo, Rui Li, Yang Xiang, Da-Cheng Yang, Zhi Guan*. Enzyme-catalyzed domino reaction: Efficient construction of spirocyclic oxindole skeleton using porcine pepsin. Catalysis Science & Technology, 2016, 6(7), 2239-2248.

[12]   Tao He, Qing-Qing Zeng, Da-Cheng Yang, Yan-Hong He*, Zhi Guan*. Biocatalytic one-pot three-component synthesis of 3,3’-disubstituted oxindoles and spirooxindole pyrans using α-amylase from hog pancreas. RSC Advances, 2015, 5 (47), 37843-37852.

[13] Zhi Guan, Yan-Li Chen, Yi Yuan, Jian Song, Da-Cheng Yang, Yang Xue, Yan-Hong He*.  Earthworm is a versatile and sustainable biocatalyst for organic synthesis. PLoS ONE, 2014, 9(8): e105284. doi:10.1371/journal.pone.0105284.

[14]   Na Gao, Yan-Li Chen, Yan-Hong He*, Zhi Guan*.   Highly efficient and large-scalable glucoamylase-catalyzed Henry reactions. RSC Advances, 2013, 3(37), 16850-16856.

[15]   Yang Xue, Ling-Po Li, Yan-Hong He*, Zhi Guan*. Protease-catalysed direct asymmetric Mannich reaction in organic solvent. Scientific Reports, 2012, 2, 761; DOI:10.1038/srep00761(2012).

[16]   Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan, Zhi Guan*. Chymopapain-catalyzed direct asymmetric Aldol reaction. Advanced Synthesis & Catalysis, 2012, 354 (4), 712-719.

[17]   Yan-Hong He*, Wen Hu, Zhi Guan*.Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme. The Journal of Organic Chemistry, 2012, 77 (1), 200-207.

[18]   Hai-Hong Li, Yan-Hong He, Yi Yuan and Zhi Guan*. Nuclease p1: A new biocatalyst for direct asymmetric aldol reaction under solvent-freeconditions. Green Chemistry, 2011, 13 (1), 185-189.

[19]   Di Wu, Yanhong He, Rongchang Tang, Zhi Guan*. The first synthesis of diethyl a,a-chlorofluorobenzylphosphonates. SYNLETT, 2009, (13), 2180-2182.

[20]   Bennett, Matthew; Guan, Zhi; Laurberg, Martin; Su, Xiaodong*. Bacillus subtilis arsenate reductase is structurally and functionally similar to low-molecular-weight protein tyrosine phosphatases (PTPs)，Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2001, 98(24), 13577-13582.