柴雅琴
柴雅琴
教授/博士生导师/重庆市学术技术带头人/教育部高等学校大学化学课程教学指导委员会委员
个人简介（300-500字）
澳门新莆京游戏网站理学博士；主持国家自然科学基金面上项目3项（在研2项），省部级项目4项。主要从事将功能化纳米材料与目标转换及核酸放大策略相结合构建电致化学发光及电化学生物传感器用于重要疾病（如癌症、心脑血管等）标志物（如microRNA、DNA、蛋白质等）超灵敏检测新方法研究，为提高疾病诊断效率提供新的技术途径。研究成果在化学领域国际顶级期刊，如J. Am. Chem. Soc., Chem. Sci.及国际重要期刊，如Anal. Chem., Chem. Commun.等上发表论文370余篇。获授权国家发明专利3项。获重庆市自然科学一等奖1项（排名第2）和重庆市科技进步一等奖1项（排名第5）。获教师明德奖1项。…
联系方式
yqchai@swu.edu.cn
研究方向
1. 纳米材料及电化学生物传感器 2. 生物电分析化学
代表性论文、专著和专利
1. Zhang, Pu; Jiang, Jie; Yuan, Ruo*; Zhuo, Ying*; Chai, Yaqin*. Highly Ordered and Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing. J. Am. Chem. Soc.,2018, 140(30), 9361-9364.
2. Li, Yunrui; Chang, Yuanyuan; Ma, Jing; Wu, Zhongyu; Yuan, Ruo*; Chai, Yaqin*. Programming a Target-Initiated Bifunctional DNAzyme Nanodevice for Sensitive Ratiometric Electrochemical Biosensing. Anal. Chem., 2019，91(9), 6127-6133.
3. Wu, Fangfang; Zhou, Ying; Zhang, Han; Yuan, Ruo*; Chai, Yaqin*. Electrochemiluminescence Peptide-Based Biosensor with Hetero-Nanostructures as Coreaction Accelerator for the Ultrasensitive Determination of Tryptase. Anal. Chem., 2018, 90(3), 2263-2270.
4. Li, Mengjie； Xiong, Chuan； Zheng, Yingning； Liang, Wenbin； Yuan, Ruo*； Chai， Yaqin*. Ultrasensitive Photoelectrochemical Biosensor Based on DNA Tetrahedron as Nanocarrier for Efficient Immobilization of CdTeQDs-Methylene Blue as Signal Probe with Near-Zero Background Noise. Anal. Chem. 2018, 90(13), 8211−8216.
5. Jiang, Xinya; Wang, Huijun, Yuan, Ruo*, Chai, Yaqin*. Functional three-dimensional porous conductive polymer hydrogels for sensitive electrochemiluminescence in situ detection of H2O2 released from live cells. Anal. Chem., 2018, 90(14), 8462−8469.
6. Zhang, Xiaolong; Yang, Zhehan; Chang, Yuanyuan; Qing, Min; Yuan, Ruo*; Chai, Yaqin*. Novel 2D-DNA-Nanoprobe-Mediated Enzyme-Free-Target-Recycling Amplification for the Ultrasensitive Electrochemical Detection of MicroRNA. Anal. Chem. 2018, 90(15), 9538−9544.
7. Li, Mengjie; Tian, Xin; Liang, Wenbin; Yuan, Ruo*; Chai, Yaqin*. Ultrasensitive Photoelectrochemical Assay with PTB7-Th/CdTe Quantum Dots Sensitized Structure as Signal Tag and Benzo-4-chlorohexadienone Precipitate as Efficient Quencher. Anal. Chem.,2018,90, 14521-14526.
8. Zhang, Pu; Lin, Zongfan; Zhuo, Ying; Yuan, Ruo*; Chai, Yaqin*. Dual microRNAs-Fueled DNA Nanogears: A Case of Regenerated Strategy for Multiple Electrochemiluminescence Detection of microRNAs with Single Luminophore. Anal. Chem., 2017, 89(2), 1338-1345.
9. He, Yi; Yang, Xia; Yuan, Yuan, Ruo*; Chai, Yaqin*. "Off" to "On" surface-enhanced raman spectroscopy platform with padlock probe-based exponential rolling circle amplification for ultrasensitive detection of MicroRNA 155. Anal. Chem., 2017, 89(5), 2866-2872.
10. Jiang, Xinya; Wang, Haijun; Wang, Huijun; Zhuo, Ying; Yuan, Ruo*; Chai, Yaqin*. Electrochemiluminescence Biosensor Based on 3-D DNA Nanomachine Signal Probe Powered by Protein-Aptamer Binding Complex for Ultrasensitive Mucin 1 Detection. Anal. Chem., 2017, 89(7), 4280-4286.
11. He, Yi; Yang, Xia; Yuan; Ruo*; Chai, Yaqin*. Switchable target-responsive 3D DNA hydrogels as a signal amplification strategy combining with SERS technique for ultrasensitive detection of miRNA 155. Anal. Chem., 2017, 89(16), 8538−8544.
12. Xu, Sai; Chang, Yuanyuan; Wu, Zhongyu; Li, Yunrui; Yuan, Ruo*, Chai, Yaqin*. One DNA circle capture probe with multiple target recognition domains for simultaneous electrochemical detection of miRNA-21 and miRNA-155. Biosens. Bioelectron., 2020, 149, 111848.
13. Da, Huimei; Liu Hongyan*, Zheng, Yingning; Yuan, Ruo, Chai, Yaqin*. A highly sensitive VEGF165 photoelectrochemical biosensor fabricated by assembly of aptamer bridged DNA networks. Biosens. Bioelectron., 2018, 101, 213-218.
14. Wang, Zili, Jiang, Xinya, Yuan, Ruo*,Chai Yaqin*. N-(Aminobutyl)-N-(Ethylisoluminol) Functionalized Fe-Based Metal-Organic Frameworks with Intrinsic Mimic Peroxidase Activity for Sensitive Electrochemiluminescence Mucin1 Determination.. Biosens. Bioelectron., 2018, 121, 250-256.
15. Xia, Lingying; Li, Mengjie; Wang, Haiun; Yuan, Ruo*; Chai, Yaqin*. A novel "signal on" photoelectrochemical strategy based on dual functional hemin for microRNA assay. Chem. Commun., 2019, 55(65), 9721-9724.
16. Wen, Zhibin; Liang, Wenbin; Zhuo, Ying; Xiong, Chengyi; Zheng, Yingning; Yuan, Ruo*; Chai, Yaqin*. An ATP-fueled nucleic acid signal amplification strategy for highly sensitive microRNA detection. Chem. Commun. 2018, 54(77), 10897-10900.
17. Wen, Zhibin; Liang, Wenbin; Zhuo, Ying; Xiong, Chengyi; Zheng, Yingning; Yuan, Ruo*; Chai, Yaqin*. An efficient target-intermediate recycling amplification strategy for ultrasensitive fluorescence assay of intracellular lead ions. Chem. Commun.,2017, 53(54), 7525-7528.
18. Jiang, Xinya; Wang, Zili; Wang, Haijun; Zhuo, Ying; Yuan, Ruo*; Chai, Yaqin*. A novel metal-organic framework loaded with abundant N-(aminobutyl)-N-(ethylisoluminol) as a high-efficiency electrochemiluminescence indicator for sensitive detection of mucin1 on cancer cells. Chem. Commun., 2017, 53(70), 9705-9708.
19. Zhang, Pu; Li, Zhaoyang; Wang, Haijun; Zhuo, Ying; Yuan, Ruo*; Chai, Yaqin*. DNA nanomachine-based regenerated sensing platform: a novel electrochemiluminescence resonance energy transfer strategy for ultra-high sensitive detection of microRNA from cancer cells. Nanoscale, 2017, 9(6), 2310-2316.
20. Yang, Zhehan; Zhuo, Ying; Yuan, Ruo*; Chai, Yaqin*. Amplified impedimetric aptasensor combining target-induced DNA hydrogel formation with pH-stimulated signal amplification for the heparanase assay. Nanoscale, 2017,9(7), 2556-2562.