卓颖

国家优青、教授、博士生导师

个人简介（300-500字）

女，1980年生，重庆人。2003-2009年在澳门新莆京游戏网站分别获得分析化学硕士和博士学位；2009年至今在澳门新莆京游戏网站工作。围绕生物体内生化信息的高效获取这一关键科学问题，致力于电化学和电化学发光生物分析新材料、新方法和新原理的研究，构建了一系列检测疾病标志物蛋白、DNA、RNA及活性小分子的高灵敏生物传感器。主持国家自然科学基金青年/面上/国际(地区)合作与交流/优秀青年基金项目、教育部博士学科点专项科研基金项目、重庆市自然科学基金等6项国家及省部级项目；2019年入选重庆市英才计划首批“青年拔尖人才”；相关成果以第一作者和通讯作者在J.Am.Chem.Soc.、Chem.Sci.、Anal.Chem.、Biomaterials、Chem.Commun.和Biosens.Bioelectron.等国际重要学术期刊发表SCI论文87篇，他引次数超过3700次；授权国家发明专利3项。

联系方式

yingzhuo@swu.edu.cn

研究方向

电化学发光生物分析新方法和新技术

光\电生物传感器

功能化DNA纳米组装.

代表性论文、专著和专利（不超过20项）

1.     Pu Zhang, Jie Jiang, Ruo Yuan,* Ying Zhuo,* and Yaqin Chai*. Highly Ordered and Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing. J. Am. Chem. Soc., 2018, 140, 9361.

2.  Wei-Jia Zeng, Kun Wang, Wen-Bin Liang, Ya-Qin Chai, Ruo Yuan and Ying Zhuo*.Covalent Organic Frameworks as Micro-reactors: Confinement-enhanced Electrochemiluminescence. Chem. Sci., 2020, 11, 5410.

3. Xiao-long Zhang, Zhe-han Yang, Yuan-yuan Chang, Di Liu, Yun-rui Li, Ya-qin Chai,*  Ying Zhuo*  and Ruo Yuan*. Programmable Mismatch-fueled High-efficiency DNA Signal Converter. Chem. Sci., 2020, 11, 148.

4. Ni Liao, Mei-Chen Pan, Li Wang, Fan Yang, Ruo Yuan, and Ying Zhuo*. Swing Arm Location-Controllable DNA Walker for Electrochemiluminescence Biosensing. Anal. Chem., 2021, 93, 4051.

5. Mei-Chen. Pan, Yan-Mei. Lei, Ya-Qin. Chai, Ruo Yuan and Ying Zhuo*. In Situ Controllable Generation of Copper Nanoclusters Confined in a Poly‑L‑Cysteine Porous Film with Enhanced Electrochemiluminescence for Alkaline Phosphatase Detection. Anal. Chem., 2020, 92, 13581.

6. Mei-Ling Zhao, Wei-Jia Zeng, Ya-Qin Chai, Ruo Yuan, and Ying Zhuo*. An Affinity-Enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications. Anal. Chem., 2020, 92, 11044.

7. Fang Yang, Xin-Ya Jiang, Wen-Bin Liang, Ya-Qin Chai, Ruo Yuan, and Ying Zhuo*. 3D Matrix-Arranged AuAg Nanoclusters As Electrochemiluminescence Emitters for Click Chemistry-Driven Signal Switch Bioanalysis. Anal. Chem., 2020, 92, 2566.

8. Ni Liao, Jia-Li Liu, Ya-Qin Chai, Ruo Yuan, and Ying Zhuo*. DNA Structure Transition-Induced Affinity Switch for Biosensing Based on the Strong Electrochemiluminescence Platform from Organic Microcrystals. Anal. Chem., 2020, 92, 3940.

9. Rui Zhang, Xia Zhong, An-Yi Chen, Jia-Li Liu, Sheng-Kai Li, Ya-Qin Chai, Ying Zhuo,* and Ruo Yuan. Novel Ru(bpy)₂(cpaphen)²⁺/TPrA/TiO₂ Ternary ECL System: An Efficient Platform for the Detection of Glutathione with Mn²⁺ as Substitute Target. Anal. Chem., 2019, 91, 3681.

10. Ming-Hui Jiang, Sheng-Kai Li, Xia Zhong, Wen-Bin Liang, Ya-Qin Chai, Ying Zhuo,* and Ruo Yuan. Electrochemiluminescence Enhanced by Restriction of Intramolecular Motions (RIM): Tetraphenylethylene Microcrystals as a Novel Emitter for Mucin 1 Detection. Anal. Chem., 2019, 91, 3710.

11. Yan-Mei Lei, Rui-Xin Wen, Jia Zhou, Ya-Qin Chai, Ruo Yuan,* Ying Zhuo*. Silver Ions as Novel Coreaction Accelerator for Remarkably Enhanced Electrochemiluminescence in a PTCA−S₂O₈²⁻ System and Its Application in an Ultrasensitive Assay for Mercury Ions. Anal. Chem., 2018, 90, 6851.

12. Yu-Cheng Zhou, Xiao-Xue Ran, An-Yi Chen, Ya-Qin Chai, Ruo Yuan,* and Ying Zhuo*. Efficient Electrochemical Self-Catalytic Platform Based on L‑Cyshemin/G-quadruplex and Its Application for Bioassay. Anal. Chem., 2018, 90, 9109.

13. Xia Yang, Yan-Qing Yu, Ling-Zhi Peng, Yan-Mei Lei, Ya-Qin Chai, Ruo Yuan,* and Ying Zhuo*. Strong Electrochemiluminescence from MOF Accelerator Enriched Quantum Dots for Enhanced Sensing of Trace cTnI. Anal. Chem., 2018, 90, 3995.

14. Wei-Jia Zeng, Ni Liao, Yan-Mei Lei, Jing Zhao, Ya-Qin Chai, Ruo Yuan,⁎, Ying Zhuo^⁎. Hemin as electrochemically regenerable co-reaction accelerator for construction of an ultrasensitive PTCA-based electrochemiluminescent aptasensor. Biosens. Bioelectron., 2018, 100, 490.

15. Yan-Mei Lei, Bai-Qi Xiao, Wen-Bin Liang, Ya-Qin Chai, Ruo Yuan⁎, Ying Zhuo^⁎. A robust, magnetic, and self-accelerated electrochemiluminescent nanosensor for ultrasensitive detection of copper ion. Biosens. Bioelectron., 2018, 109, 109.

16. Sheng-Kai Li, Zhi-Ting Liu, Ji-Yang Li, An-Yi Chen, Ya-Qin Chai, Ruo Yuan,* and Ying Zhuo*. Enzyme-free Target Recycling and Double-Output Amplification System for Electrochemiluminescent Assay of Mucin 1 with MoS₂ Nanoflowers as Co-reaction Accelerator. ACS Appl. Mat. Interfaces., 2018, 10, 14483-14490.

17. Yan-Mei Lei, Jia Zhou, Ya-Qin Chai, Ying Zhuo,* and Ruo Yuan*. SnS2 Quantum Dots as New Emitters with Strong Electrochemiluminescence for Ultrasensitive Antibody Detection. Anal. Chem., 2018, 90, 12270.

18. Jia-Li Liu, Zhi-Ling Tang, Ying Zhuo*, Ya-Qin Chai, Ruo Yuan*. A Novel Ternary Electrochemiluminescence System Based on Rubrene Microrods as Luminophore and Pt Nanomaterials as Coreaction Accelerator for Ultrasensitive Detection of MicroRNA from Cancer Cells. Anal. Chem., 2017, 89, 9108.

19. Min Zhao, An-Yi Chen, Dan Huang, Ying Zhuo*, Ya-Qin Chai, Ruo Yuan*. MoS₂ Quantum Dots as New Electrochemiluminescence Emitters for Ultrasensitive Bioanalysis of Lipopolysaccharide. Anal. Chem., 2017, 89, 8335.

20. An-Yi Chen, Min Zhao, Ying Zhuo*, Ya-Qin Chai, Ruo Yuan*. Hollow Porous Polymeric Nanospheres of Self-Enhanced Ruthenium Complex with Improved Electrochemiluminescent Efficiency for Ultrasensitive Aptasensor Construction. Anal. Chem., 2017, 89, 9232.