张璞

（教授）

自2013年9月至2018年6月就读于澳门新莆京游戏网站，获得分析化学博士学位，师从袁若、柴雅琴教授。自2018年7月至2021年11月，在以色列耶路撒冷希伯来大学化学系从事博士后研究，合作导师为中国科学院外籍院士itamar willner教授。主要研究领域为DNA纳米技术和新型核酸功能纳米材料，利用发光分析平台，实现了针对miRNA的发光分析传感、细胞成像及药物释放的诊疗一体化研究。迄今为止，共发表文章27篇，以第一作者发表文章13篇，其中影响因子大于15的文章4篇，包括J. Am. Chem. Soc. 1篇（高被引论文）、ACS Nano 3篇、Chem. Sci. 4篇、Anal. Chem. 3篇、Nanoscale 1篇，他引次数1000余次，个人H因子16（基于谷歌学术）。于2021年荣获重庆市科学技术奖一等奖（参与人排名第4），荣获2019年重庆市优秀博士学位论文，荣获第十六届国际电化学会议墙报“Top 20”奖项，荣获第十二届全国化学传感器学术会议墙报一等奖。主持2023年国家自然科学青年基金，2022年重庆市留学创业项目基金，2022年重庆市国家自然科学基金。

联系方式

puzhang@swu.edu.cn

569323315@qq.com

研究方向

核酸功能纳米材料

DNA纳米技术

发光分析传感

代表性论文、专著和专利

[1] P. Zhang, J. Jiang, R. Yuan, Y. Zhuo, Y. Chai. Highly Ordered And Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing. J. Am. Chem. Soc., 2018, 140, 9361-9364.

[2] P. Zhang, Y. Ouyang, Y. S. Sohn, M. Fadeev, O. Karmi, R. Nechushtai, I. Stein, E. Pikarsky, I. Willner. miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn (II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles. ACS nano, 2022, 16, 1791-1801.

[3] P. Zhang, Y. Ouyang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner. pH-And miRNA-Responsive DNA-Tetrahedra/Metal-Organic Framework Conjugates: Functional Sense-And-Treat Carriers. ACS nano, 2021, 15, 6645-6657.

[4] P. Zhang, L. Yue, M. Vazquez-Gonzalez, Z. Zhou, W.-H. Chen, Y. S. Sohn, R. Nechushtai, I. Willner. MicroRNA-Guided Selective Release of Loads from Micro-/Nanocarriers Using Auxiliary Constitutional Dynamic Networks. ACS Nano, 2020, 14, 1482-1491.

[5] P. Zhang, A. Fischer, Y. Ouyang, Y. S. Sohn, R. Nechushtai, J. J. Zhang, H. Tian, C. H. Fan, I. Willner. Biocatalytic Cascades and Intercommunicated Biocatalytic Cascades in Microcapsule Systems, Chem. Sci., 2022, 13, 7437-7448.

[6] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, O. Karmi, R. Nechushtai, I. Willner. Topologically switchable and gated transcription machinery, Chem. Sci., 2022, 13, 10555-10565.

[7] P. Zhang, A. Fischer, Y. Ouyang, J. Wang, Y. S. Sohn, R. Nechushtai, E. Pikarsky, C. Fan, I. Willner. Aptamer-Modified DNA Tetrahedra-Gated Metal-Organic Framework Nanoparticle Carriers for Enhanced Chemotherapy or Photodynamic Therapy. Chem. Sci., 2021, 12, 14473-14483.

[8] P. Zhang, Y. Ouyang, I. Willner. Multiplexed And Amplified Chemiluminescence Resonance Energy Transfer (CRET) Detection of Genes And microRNAs Using Dye-Loaded Hemin/G-quadruplex-Modified UiO-66 Metal-Organic Framework Nanoparticles. Chem. Sci., 2021, 12, 4810-4818.

[9] P. Zhang, Z. Lin, Y. Zhuo, R. Yuan, Y. Chai. Dual microRNAs-Fueled DNA Nanogears: A Case of Regenerated Strategy for Multiple Electrochemiluminescence Detection of microRNAs with Single Luminophore. Anal. Chem., 2017, 89, 1338-1345.

[10] P. Zhang, Y. Zhuo, Y. Chang, R. Yuan, Y. Chai, Electrochemiluminescent Graphene Quantum Dots as A Sensing Platform: A Dual Amplification for microRNA Assay. Anal. Chem., 2015, 87, 10385-10391.

[11] P. Zhang, X. Wu, Y. Chai R. Yuan. An “Off-On” Electrochemiluminescent Biosensor Based on DNAzyme-Assisted Target Recycling And Rolling Circle Amplifications for Ultrasensitive Detection of microRNA. Anal. Chem., 2015, 87, 3202-3207.

[12] P. Zhang, Z. Li, H. Wang, Y. Zhuo, R. Yuan, Y. Chai. DNA Nanomachine-based Regenerated Sensing Platform: A Novel Electrochemiluminescence Resonance Energy Transfer Strategy for Ultra-High Sensitive Detection of microRNA from Cancer Cells. Nanoscale, 2017, 9, 2310-2316.

      [13]  P. Zhang, X. Wu, Y. Chai R. Yuan. An Electrochemiluminescent microRNA Biosensor Based on Hybridization Chain Reaction Coupled with Hemin As The Signal Enhancer. Analyst, 2014, 139, 2748-2753.